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    220107-65-3

    Catalog No. EBD2301903

    CAS 220107-65-3

    Name 2-Amino-5-(trifluoromethyl)benzyl alcohol

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    Basic Information

    Synonyms: 2-Amino-5-(trifluoromethyl)benzylalcohol

    Molecular Formula: C8H8F3NO

    Molecular Weight: 191.15

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers

    Product Description:
    2-Amino-5-(trifluoromethyl)benzyl alcohol is a functionalized aromatic building block featuring a primary amine, a benzylic alcohol, and a trifluoromethyl group at the 5-position. The trifluoromethyl moiety is a key pharmacophore in medicinal chemistry, enhancing metabolic stability, lipophilicity, and bioavailability of drug candidates. This compound serves as a versatile intermediate for synthesizing small-molecule drug fragments, particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) therapeutics. Its dual reactive sites (amino and hydroxyl) allow for selective derivatization, enabling the construction of complex heterocyclic or conjugated systems. Additionally, it is employed as a specialty synthetic building block for introducing trifluoromethyl-substituted aniline motifs into organic molecules, making it valuable in both pharmaceutical research and advanced organic synthesis.
    Physical Properties
    mg g kg ml l t