2 - (4 - Boc - piperazine)pyridine - 5 - boronic acid pinacol ester, CAS No. 496786-98-2

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496786-98-2

Catalog No. EBD12740

CAS 496786-98-2

Name 2 - (4 - Boc - piperazine)pyridine - 5 - boronic acid pinacol ester

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Basic Information

Synonyms: 6-(4-Boc-1-piperazinyl)pyridine-3-boronicacidpinacolester tert-butyl4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]tetrahydro-1(2H)-pyrazinecarboxylate tert-Butyl4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Piperazine-1-CarboxylicAcidTert-ButylEster tert-butyl4-[5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate tert-Butyl4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine-1-carboxylate tert-butyl4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-1-piperazinecarboxylate 1-piperazinecarboxylicacid,4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-,1,1-dimethylethylester 2-(4-Boc-piperazine)pyridine-5-boronicacidpinacolester tert-Butyl4-[5-(4,4,5,5-tetra

Molecular Formula: C20H32BN3O4

Molecular Weight: 389.3

MDL Number: MFCD04039875

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

Product Description:

2-(4-Boc-piperazine)pyridine-5-boronic acid pinacol ester is a heterocyclic boronic ester derivative. It features a pyridine ring substituted with a Boc-protected piperazine group at the 2-position and a boronic acid pinacol ester moiety at the 5-position. This bifunctional structure makes it a versatile building block in organic synthesis. This compound is primarily utilized as a key intermediate in medicinal chemistry research and pharmaceutical development. The boronic ester group enables its participation in Suzuki-Miyaura cross-coupling reactions, a fundamental method for constructing biaryl and heterobiaryl systems. The Boc-protected piperazine moiety is a common pharmacophore found in numerous bioactive molecules targeting central nervous system disorders, oncology, and other therapeutic areas. It serves as a crucial precursor for synthesizing potential drug candidates, particularly in the discovery of kinase inhibitors and other small molecule therapeutics. As a protected boronic acid derivative, it offers improved stability and handling compared to the free boronic acid. Its application is central to constructing complex molecular architectures for biological screening and structure-activity relationship (SAR) studies.

Physical Properties

Melting Point: 165-169 °C

Boiling Point: 515.9 °C at 760 mmHg

Flash Point: 265.8 °C

Density: 1.14 g/cm3