6-Methyl-2-(methylthio)pyrimidin-4-ol, CAS No. 6328-58-1

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6328-58-1

Catalog No. EBD22737

CAS 6328-58-1

Name 6-Methyl-2-(methylthio)pyrimidin-4-ol

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Basic Information

Synonyms: 6-Methyl-2-methylsulfanyl-pyrimidin-4-ol 4(1H)-pyrimidinone,6-methyl-2-(methylthio)- 4(3H)-Pyrimidinone,6-methyl-2-(methylthio)- 4-pyrimidinol,6-methyl-2-(methylthio)- 6-Methyl-2-(methylsulfanyl)pyrimidin-4(1H)-one 6-Methyl-2-(methylsulfanyl)pyrimidin-4(3H)-one 6-Methyl-2-(methylsulfanyl)pyrimidin-4-ol 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one 6-methyl-2-(methylthio)pyrimidin-4-ol 6-methyl-2-mercapto-4-hydroxypyrimidine

Molecular Formula: C6H8N2OS

Molecular Weight: 156.21

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents

Product Description:

6-Methyl-2-(methylthio)pyrimidin-4-ol is a pyrimidine derivative characterized by a hydroxyl group at the 4-position and a methylthio group at the 2-position. It serves as a crucial synthetic intermediate in the pharmaceutical industry. Its primary and most significant application is in the synthesis of the antineoplastic drug Capecitabine (Xeloda®), a prodrug of 5-fluorouracil used in the treatment of colorectal and breast cancers. This compound is a key building block in the multi-step synthesis of Capecitabine, highlighting its direct role in the production of an active pharmaceutical ingredient (API). As a heterocyclic intermediate with specific functional groups, it is also relevant in the synthesis of other pyrimidine-based compounds. It is typically handled as a solid and requires standard laboratory safety precautions for handling fine chemicals.

Physical Properties

Melting Point: 224-226 °C