(6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-androsta-1,4-diene-17-carbothioic acid CAS No.80474-45-9 / Cat No.EBD54833
S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate
(6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester
fluticasone propionate intermediate
6,9-difluoro-11b-hyrdoxy-16-methyl-3-oxo-17-propionyloxyandrosta-1,4-diene-17b-carbpthiocacid
6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-
androsta-1,4-diene-17-carbothioic acid
oxopropoxy)-, (6α,11β,16α,17α)-
6a,9a-difluoro-l1~-hydroxy-l6a-methyl-17a-propionyloxy-3-oxoandrosta-l,4-diene-l7~-carbothioic acid
Properties
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Appearance:
white solid
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Density:
1.315 g/cm3
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Melting point:
158-160 °C
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Boiling point:
563.337 °C at 760 mmHg
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Flashing point:
294.496 °C
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Vapour pressure:
0mmHg at 25°C
NMR Spectrum
Prediction： H NMR (400 MHz in CDCh), delta: 1.06(s, 3H), 1.16(t, J=7.52Hz, 3H), 1.20-1.25(m, I H), 1.39(d.J=7.23Hz, 3H), 1.54(s, 3H), 1.67-2.05(m, 4H), 2.22-2.80(m, 4H), 2.39(q, J=7.69Hz, 2H).4.45(br-d, J=7.69Hz, l H),5.30-5.50(m, IH), 6.38(d, J=9.93Hz, I H), 6.43(s, I H), 7.15(dd.J=I 0.17Hz, I H).
1H NMR
13C NMR
