4-(Imidazol-1-yl)phenol, CAS No. 10041-02-8

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10041-02-8

Catalog No. EBD44962

CAS 10041-02-8

Name 4-(Imidazol-1-yl)phenol

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Basic Information

Synonyms: labotest-bblt00440917 1-(4'-hydroxyphen-1-yl)imidazole 1-(4-hydroxyphenyl)imidazole n-(4-hydroxyphenyl)imidazole p-(1-imidazolyl)phenol 1-(p-Hydroxyphenyl)imidazole 4-(1H-Imidazol-1-yl)phenol 4-(Imidazol-1-yl)phenol

Molecular Formula: C9H8N2O

Molecular Weight: 160.17

MDL Number: MFCD00005281

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers

Product Description:

4-(1H-Imidazol-1-yl)phenol is an organic compound featuring a phenol group linked to an imidazole ring via a methylene bridge. It serves as a versatile bifunctional building block in medicinal chemistry and organic synthesis. Its primary application is as a key intermediate in the synthesis of biologically active molecules, particularly in the development of pharmaceutical candidates. The phenolic hydroxyl group allows for further derivatization (e.g., etherification, esterification), while the imidazole ring is a privileged heterocycle found in many drugs, often acting as a ligand for metal ions or participating in hydrogen bonding interactions within biological targets. This makes it valuable for constructing compounds with potential therapeutic applications. As a synthetic intermediate, it is used to prepare more complex structures, including ligands for catalysis and functional materials. Its dual functionality (phenol and imidazole) provides handles for diverse chemical modifications, making it a useful reagent in research laboratories for constructing heterocyclic libraries and exploring structure-activity relationships.

Physical Properties

Melting Point: 204-206 °C(lit.)

Boiling Point: 350.7 °C at 760 mmHg

Flash Point: 165.9 °C

Density: 1.2 g/cm3

Solubility: Soluble

Analytical Data

Appearance: yellow solid