4-Amino-2,6-dichloropyrimidine, CAS No. 10132-07-7

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10132-07-7

Catalog No. EBD6858

CAS 10132-07-7

Name 4-Amino-2,6-dichloropyrimidine

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Basic Information

Synonyms: 2,6-dichloropyrimidin-4-amine 2,4-Dichloro-6-aminopyrimidine 2,6-dichloro-4-pyrimidinamin 2,6-dichloro-4-aminopyrimidine 4-amino-2,6-dichloropyrimidine97% 2,6-dichloro-pyrimidin-4-ylamine 4-amino-2,6-dimethoxypyrimidinesulphadimethoxine 4-Amino-2,6-dichloropyrimidine

Molecular Formula: C4H3Cl2N3

Molecular Weight: 163.99

MDL Number: MFCD00038015

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

4-Amino-2,6-dichloropyrimidine is a white to off-white crystalline powder with the molecular formula C4H3Cl2N3. It is a versatile heterocyclic building block characterized by the presence of two chlorine atoms and one amino group on the pyrimidine ring, making it a valuable intermediate for nucleophilic substitution reactions. This compound is primarily used as a key intermediate in the synthesis of various pharmaceutical agents. Its most notable application is in the production of sulfonamide diuretics, such as hydrochlorothiazide and related thiazide-class drugs, which are widely used to treat hypertension and edema. The reactive chlorine atoms allow for the construction of more complex fused heterocyclic systems essential for biological activity. Beyond pharmaceuticals, 4-amino-2,6-dichloropyrimidine serves as a precursor in agrochemical synthesis and the development of other nitrogen-containing heterocycles for material science. It requires careful handling as it may cause skin and eye irritation.

Physical Properties

Melting Point: 258-267 °C

Boiling Point: 323.5 °C at 760 mmHg

Flash Point: 149.5 °C

Density: 1.606 g/cm3

Storage: 2-8°C

Analytical Data

Appearance: cream to light brown crystalline powder