5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole, CAS No. 102625-64-9

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102625-64-9

Catalog No. EBD35810

CAS 102625-64-9

Name 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole

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Basic Information

Synonyms: 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole 5-Difluoromethoxy-2-[(3,4-dimethoxy-2-pyridinyl)methyl]thio-1H-benzimidazole 5-(Difluoromethoxy)-2[[(3,4-dimethoxy-2-pyridinyl)methyl]-thio]-1H-benzimidazole 5-Difluoromethoxy-2-[(3,4-methoxy-2-pyridinylmethylthio)-1H-benzimidozole 5-Diflyoromethoxy-2-[(3,4-dimethoxy-2-pyridinyl)methyl]thio-1H-benzimidazole 6-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole 5-(Diflyoromethoxy)-2-[(3,4-dimethoxy-2-pyridinyl)methyl]thio-1H-benzimidazole 5-(Diflyoromethoxy)-2-[(3,4-dimet

Molecular Formula: C16H15F2N3O3S

Molecular Weight: 367.37

MDL Number: MFCD07368273

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Digestive System Drugs

Product Description:

Pantoprazole sulfide is a key intermediate in the synthesis of pantoprazole sodium, a proton pump inhibitor (PPI) widely used in the treatment of gastric acid-related disorders such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. Chemically, it is a benzimidazole derivative containing a sulfinyl group, which is a crucial structural feature for its biological activity. This compound serves as the penultimate precursor in the manufacturing process of pantoprazole. The final step typically involves the oxidation of the sulfide moiety to the corresponding sulfoxide (pantoprazole). Its primary and exclusive industrial application is in the pharmaceutical production of the active pharmaceutical ingredient (API) pantoprazole. As a critical intermediate, its quality and purity directly impact the efficacy and safety of the final drug product. The synthesis and handling of pantoprazole sulfide are conducted under controlled conditions in accordance with Good Manufacturing Practices (GMP) to ensure compliance with pharmaceutical regulatory standards. Its role is confined to the synthesis pathway and it is not used as a final therapeutic agent itself.

Physical Properties

Melting Point: 110-118°C

Boiling Point: 526.293 °C at 760 mmHg

Flash Point: 272.1 °C

Density: 1.43 g/cm3

Analytical Data

Appearance: beige solid