2-Amino-6-chloropurine, CAS No. 10310-21-1

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10310-21-1

Catalog No. EBD1476

CAS 10310-21-1

Name 2-Amino-6-chloropurine

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Basic Information

Synonyms: 6-chloroguaninecrystalline 6-chloro-7H-purin-2-ylamine 6-Chloroguanine 6-chloro-5H-purin-2-amine 6-chloro-7H-purin-2-amine 2-Amino-6-chloro-purine auroraka-689 6-chloro-2-aminopurine 6-chloro-9h-purin-2-ylamine timtec-bbsbb003863 2-amino-6-chloro-purin 2-Amino-6-chloropurine

Molecular Formula: C5H4ClN5

Molecular Weight: 169.57

MDL Number: MFCD00075252

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

Product Description:

6-Chloroguanine is a halogenated derivative of the purine base guanine. It is a white to off-white crystalline powder with a molecular formula of C5H4ClN5O. This compound is a key heterocyclic building block in organic synthesis, particularly in the preparation of nucleoside analogs. Its primary application is as a crucial pharmaceutical intermediate in the synthesis of antiviral and anticancer drugs. It serves as a precursor for the production of nucleoside analogs such as 6-chloro-2'-deoxyguanosine and other modified guanine derivatives, which are investigated for their therapeutic potential. These analogs often function by interfering with DNA replication or viral polymerase activity. As a modified nucleobase, it is also used in biochemical research to study nucleic acid structure and function, and in the development of oligonucleotide probes. Handling requires standard laboratory precautions due to its potential irritant properties.

Physical Properties

Melting Point: >300 °C(lit.)

Boiling Point: 623.9 °C at 760 mmHg

Flash Point: 331.1 °C

Density: 1.77 g/cm3

Solubility: 1.7 g/L (20 ºC)

Storage: Keep Cold

Analytical Data

Appearance: white to light yellow crystal powder