Diethyl (2-oxopropyl)phosphonate, CAS No. 1067-71-6

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

1067-71-6

Catalog No. EBD4639

CAS 1067-71-6

Name Diethyl (2-oxopropyl)phosphonate

Get Quote

Basic Information

Synonyms: (2-oxo-propyl)-phosphonicaciddiethylester acetylphosphonicaciddiethylester diethylacetylphosphonate diethyl(2-oxopropyl)phosphonate auroraka-1476 diethyl(2-oxopropyl)phosphonate,97% diethylacetylmethylphosphonate,97% diethyl2-oxopropylphosphonatediethylacetylmethylphosphonate 6-Ethenyl-6-(2-methoxyethoxy)-2,5,7,10-tetraoxa-6-silaundecane Tris(2-methoxyethoxy)vinylsilane Diethylacetonylphosphonate diethylphosphonoacetone diethyl2-oxopropanephosphonate 1-diethoxyphosphinyl-2-propanone diethyl(acetylmethyl)phosphonate 2-oxopropylphosphonicaciddiethylester phosphonicacid,(2-oxopropyl)-,diethylester(9ci) phosphonicacid,acetonyl-,diethylester(6ci,7ci,8ci)

Molecular Formula: C7H15O4P

Molecular Weight: 194.17

MDL Number: MFCD00044728

Categories: Synthetic Chemistry > Basic Synthetic Reagents > C-C Bond Formation Reagents

Product Description:

Diethyl (2-oxopropyl)phosphonate, also known as diethyl acetonylphosphonate, is an organophosphorus compound with the molecular formula C7H15O4P and a molecular weight of 194.17 g/mol. It features a phosphonate ester group directly attached to a 2-oxopropyl (acetonyl) moiety, making it a versatile synthetic building block. This compound is primarily utilized in organic synthesis as a key reagent for the Horner-Wadsworth-Emmons (HWE) reaction. The presence of the phosphonate group adjacent to the carbonyl allows it to act as a stabilized carbanion precursor, enabling the formation of ж┴,ж┬-unsaturated ketones via olefination of aldehydes and ketones. It is also employed in the synthesis of phosphonate-containing pharmaceuticals, agrochemicals, and natural product analogs, where the phosphonate group can serve as a bioisostere for phosphate esters. As a stable and reactive intermediate, it is widely used in research laboratories for constructing carbon-carbon double bonds and introducing phosphorus functionality into complex molecules. Its handling requires standard precautions for organophosphorus compounds, including use in a fume hood and avoidance of skin contact.

Physical Properties

Boiling Point: 126 °C/9 mmHg(lit.)

Flash Point: >113 °C

Density: 1.01 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.433(lit.)