2-(Trifluoromethyl)pyridin-3-amine, CAS No. 106877-32-1

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106877-32-1

Catalog No. EBD1956714

CAS 106877-32-1

Name 2-(Trifluoromethyl)pyridin-3-amine

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Basic Information

Synonyms: 2-trifluoromethyl-3-Aminopyridine 3-Amino-2-(trifluoromethyl)-Pyridine 2-(trifluoromethyl)pyridin-3-amine 3-Amino-2-trifluoromethylpyridine 3-Amino-2-(trifluoromethyl)pyridine

Molecular Formula: C6H5F3N2

Molecular Weight: 162.11

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

3-Amino-2-(trifluoromethyl)pyridine is an organic compound featuring a pyridine ring substituted with an amino group at the 3-position and a trifluoromethyl group at the 2-position. This structure combines the basicity of an aromatic amine with the unique electronic and steric properties imparted by the trifluoromethyl group. Its primary application is as a versatile pharmaceutical intermediate. The presence of both an amino group and a trifluoromethylated heterocyclic core makes it a valuable building block in medicinal chemistry, particularly for the synthesis of drug candidates targeting various therapeutic areas. The amino group serves as a handle for further derivatization (e.g., amide formation, reductive amination), while the trifluoromethyl group is a common pharmacophore known to enhance metabolic stability, lipophilicity, and binding affinity. Consequently, this compound is widely utilized in research and development for constructing complex molecules. It is commercially available from suppliers specializing in fine chemicals and advanced intermediates for drug discovery.

Physical Properties

Melting Point: 68-72 °C

Boiling Point: 221.217 °C at 760 mmHg

Flash Point: 87.589 °C

Density: 1.369 g/cm3

Safety Information

Packing Level: III

Hazard Category: 6.1

Transport Codes: 2811