Potassium 1,3-dioxoisoindolin-2-ide, CAS No. 1074-82-4

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1074-82-4

Catalog No. EBD8109

CAS 1074-82-4

Name Potassium 1,3-dioxoisoindolin-2-ide

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Basic Information

Synonyms: Potassium1,3-dioxoisoindolin-2-ide 1h-isoindole-1,3(2h)-dione,potassiumsalt n-potassiophthalimide potassiumphthalimidate phthalimidepotassium phthalimide,potassiumderivative phthalimidepotassiumsalt potassiumphthalimide potassiumphthalamide PotassiumPhthalomide Potassiumphtalimide POTASSIUMPHTALAMIDE n-potassiumphthalimide PotassiumPhthalylimide99% Potassiumphtalimide,97% Phthlimide 1,3-dihydro-1,3-dioxoisoindolepotassiumsalt 1H-isoindole-1,3(2H)-dione potassium1-oxo-1H-isoindol-3-olate 1-oxo-1H-isoindol-3-olate 1H-isoindole-1,3(2H)-dione,potassiumsalt(1:1) potas

Molecular Formula: C8H4KNO2

Molecular Weight: 185.22

MDL Number: MFCD00005887

Categories: Materials Chemistry > Optoelectronic and Organic Semiconductor Materials > Dye Precursors Synthetic Chemistry > Basic Synthetic Reagents > Other Basic Synthetic Reagents Synthetic Chemistry > Organic Building Blocks > Phosphorus Compounds

Product Description:

Potassium 1,3-dioxoisoindolin-2-ide, commonly known as potassium phthalimide, is a white to off-white crystalline solid with the molecular formula C8H4KNO2. It is the potassium salt of phthalimide, featuring a stable isoindoline-1,3-dione core with a potassium cation. This compound is highly soluble in polar solvents and serves as a key synthetic building block in organic chemistry. Its primary application is as a precursor in the Gabriel synthesis, a classical method for producing primary amines from alkyl halides. The nucleophilic nitrogen atom in potassium phthalimide readily undergoes substitution reactions, followed by hydrazinolysis or hydrolysis to yield the desired amine. This makes it indispensable in the preparation of pharmaceutical intermediates, including amino acids, heterocyclic compounds, and drug candidates. Additionally, it is used in the synthesis of agrochemicals and specialty chemicals. Potassium phthalimide is stable under normal conditions but should be handled with care to avoid moisture and strong acids. Its role as a versatile reagent in both academic research and industrial production underscores its importance in constructing nitrogen-containing molecules.

Physical Properties

Melting Point: >300 °C(lit.)

Boiling Point: 359 ºC at 760 mmHg

Flash Point: 170.9 ºC

Density: 1.367 g/cm3

Storage: Store at RT.

Analytical Data

Appearance: greenish white powder