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    1214377-42-0

    Catalog No. EBD209965

    CAS 1214377-42-0

    Name 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine

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    Basic Information

    Synonyms: Pyridine,5-bromo-2-methoxy-3-(trifluoromethyl)- 5-Bromo-2-methoxy-3-trifluoromethyl-pyridine 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine

    Molecular Formula: C7H5BrF3NO

    Molecular Weight: 256.02

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine is a halogenated pyridine derivative featuring bromine, methoxy, and trifluoromethyl substituents. This specific substitution pattern makes it a valuable and versatile building block in organic synthesis, particularly for constructing more complex heterocyclic systems. Its primary application is as a key pharmaceutical intermediate. The presence of the bromine atom allows for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), while the trifluoromethyl group is a common pharmacophore known to enhance metabolic stability, lipophilicity, and binding affinity in drug molecules. This compound is frequently employed in the research and development of active pharmaceutical ingredients (APIs), especially in the areas of kinase inhibitors and central nervous system (CNS) agents. As a functionalized pyridine, it serves as a crucial synthetic precursor. Its reactivity profile enables medicinal chemists to efficiently introduce the 2-methoxy-3-trifluoromethylpyridine scaffold into target molecules, accelerating the discovery of novel therapeutic candidates.
    Physical Properties

    Storage: −20°C

    mg g kg ml l t