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    1282518-60-8

    Catalog No. EBD2219455

    CAS 1282518-60-8

    Name 1-Isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

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    Basic Information

    Synonyms: 1-Isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

    Molecular Formula: C12H21BN2O2

    Molecular Weight: 236.12

    Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

    Product Description:
    1-Isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is an organic compound featuring a pyrazole heterocycle substituted with an isopropyl group at the N1 position and a pinacol boronate ester group at the C5 position. This structure classifies it as a heterocyclic boronic ester derivative. This compound serves as a versatile building block in modern synthetic chemistry, particularly in transition-metal-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura coupling. The boronate ester group acts as a stable and reactive handle for forming carbon-carbon bonds, allowing for the introduction of the substituted pyrazole moiety into more complex molecular architectures. Pyrazole rings are privileged scaffolds found in numerous pharmaceuticals, agrochemicals, and functional materials. As a specialized synthetic intermediate, its primary utility lies in medicinal chemistry and materials science research for constructing target molecules. It is typically handled under inert atmosphere conditions due to the potential sensitivity of the boronate ester to protic solvents and oxygen.
    Physical Properties

    Boiling Point: 327.3±15.0 °C at 760 mmHg

    Flash Point: 151.7±20.4 °C

    Density: 1.0±0.1 g/cm3

    mg g kg ml l t