4-Chloro-3-nitropyridine, CAS No. 13091-23-1

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

13091-23-1

Catalog No. EBD574586

CAS 13091-23-1

Name 4-Chloro-3-nitropyridine

Get Quote

Basic Information

Synonyms: 4-Chlor-3-nitropyridine Pyridine,4-chloro-3-nitro- 4-chloro-3-nitro-pyridine 3-nitro-4-chloropyridine 4-chlor-3-nitro-pyridin 4-chloro-3-nitropyridine98% 4-chloro-3-nitropyridine4-chloro-3-nitropyridine 4-chloro-3-nitropyridine,95%,maycont.variableamountsofoligomers 4-chloro-3-nitropyridine,maycont.variableamountsofoligomers 4-chloro-3-nitropyridine,tech. 4-Chloro-3-nitropyridine

Molecular Formula: C5H3ClN2O2

Molecular Weight: 158.54

MDL Number: MFCD02683025

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

4-Chloro-3-nitropyridine is a heterocyclic aromatic compound featuring a pyridine ring substituted with a chlorine atom at the 4-position and a nitro group at the 3-position. It is a pale yellow to yellow crystalline solid. The molecule serves as a versatile bifunctional building block, where the chlorine atom is susceptible to nucleophilic aromatic substitution (SNAr) reactions, and the nitro group can be reduced to an amine or participate in other transformations. Its primary and most significant application is as a key pharmaceutical intermediate. It is extensively used in the synthesis of various biologically active molecules, particularly in the development of kinase inhibitors and other drug candidates. For instance, it is a crucial precursor in the synthesis of the anti-cancer drug Crizotinib and other c-Met inhibitors. The compound's reactivity allows for the sequential introduction of different functional groups, enabling the construction of complex medicinal chemistry scaffolds. As a halogenated nitroheterocycle, it requires careful handling due to its potential toxicity and irritant properties. It is typically stored under inert conditions and away from strong reducing agents. Its dual functionality makes it a valuable and widely used reagent in both medicinal chemistry research and process development for active pharmaceutical ingredients (APIs).

Physical Properties

Melting Point: 35-50 °C

Boiling Point: 246.5 °C at 760 mmHg

Flash Point: 102.9 °C

Density: 1.489 g/cm3

Storage: −20°C

Safety Information

Packing Level: III

Hazard Category: 6.1

Transport Codes: 2811

Analytical Data

Appearance: Snuff color to brown powder