Ne-Boc-L-lysine tert-butyl ester hydrochloride, CAS No. 13288-57-8

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13288-57-8

Catalog No. EBD7118

CAS 13288-57-8

Name Ne-Boc-L-lysine tert-butyl ester hydrochloride

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Basic Information

Synonyms: lysine(boc)-otbuhcl h-lys(boc)-obuthcl n-epsilon-t-boc-l-lysinet-butylesterhydrochloride n-epsilon-t-butoxycarbonyl-l-lysinet-butylesterhydrochloride n-epsilon-butoxycarbonyl-l-lysinet-butylesterhcl n-epsilon-boc-l-lysinet-butylesterhydrochloride n-epsilon-boc-l-lysinet-butylesterhydrochloridesalt H-Lys(Boc)-OtBuHCl Ne-Boc-L-lysinetert-butylesterhydrochloride H-Lys(Boc)-OtBu.HCl H-Lys(Boc)-OBut*HCl tert-butylN~6~-(tert-butoxycarbonyl)lysinate H-Lys(Boc)-OtBu·HCl

Molecular Formula: C15H31ClN2O4

Molecular Weight: 338.87

MDL Number: MFCD00038899

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

N(e)-Boc-L-lysine tert-butyl ester hydrochloride is a protected derivative of the essential amino acid L-lysine. It features orthogonal protecting groups: a tert-butyloxycarbonyl (Boc) group on the epsilon (ε) amine and a tert-butyl ester on the carboxyl group. This white to off-white crystalline powder is a crucial building block in peptide synthesis, particularly for the solid-phase synthesis of peptides and peptidomimetics. Its primary application is in the pharmaceutical industry as a key intermediate for the synthesis of therapeutic peptides and peptide-based drugs. The Boc group on the side chain allows for selective deprotection under acidic conditions, enabling the controlled elongation of peptide chains. This compound is instrumental in research and development of bioactive peptides targeting various diseases. The orthogonal protection strategy makes it a versatile and valuable reagent in medicinal chemistry. It is widely used in the preparation of complex peptides where the selective manipulation of the lysine side chain is required. Proper handling is advised as it may cause skin and eye irritation.

Physical Properties

Storage: -15°C