L-Valine tert-butyl ester hydrochloride, CAS No. 13518-40-6

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13518-40-6

Catalog No. EBD11404

CAS 13518-40-6

Name L-Valine tert-butyl ester hydrochloride

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Basic Information

Synonyms: h-val-otbul-valinetert-butylesterhcl l-valine1,1-dimethylethylesterhydrochloride (s)-tert-butyl2-amino-3-methylbutanoatehydrochloride h-val-otbu·hcll-valinetert·butylesterhydrochloride l-h-val-otbuhcl h-val-otbu tert-butyl2-amino-3-methyl-butanoatehydrochloride H-Val-OBut*HCl H-Val-OtBu.HCl L-VALINE-OTBUHCL L-VALINE-T-BUTYLESTERHYDROCHLORIDE H-Val-OtBu• H-Val-OtBu·HCl L-Valinetertbutylesterhydrochloride l-valinetert-butylesterhydrochloride DL-Alaninemethylesterhydrochloride

Molecular Formula: C9H20ClNO2

Molecular Weight: 209.71

MDL Number: MFCD00034863

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

L-Valine tert-butyl ester hydrochloride is a white to off-white crystalline powder derived from the essential amino acid L-valine. It is a protected form of valine where the carboxylic acid group is esterified with a tert-butyl group, and the amino group is present as its hydrochloride salt. This protection strategy is crucial in synthetic chemistry to prevent unwanted side reactions during peptide bond formation. This compound serves as a key chiral building block in the synthesis of peptides and peptidomimetics. Its primary application is in the pharmaceutical industry as an intermediate for the production of various active pharmaceutical ingredients (APIs), particularly those with complex peptide structures. The tert-butyl ester protecting group is stable under many reaction conditions but can be readily removed under acidic conditions, making it a versatile tool in solid-phase and solution-phase peptide synthesis. As a derivative of a proteinogenic amino acid, it is also utilized in biochemical research and the development of novel bioactive compounds. Handling requires standard precautions for laboratory chemicals, and it should be stored in a cool, dry place.

Physical Properties

Boiling Point: 241.7 °C at 760 mmHg

Flash Point: 100 °C

Storage: Store at 0-5°C