1-bromomethyl-3,5-difluoro-benzene, CAS No. 141776-91-2

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141776-91-2

Catalog No. EBD960030

CAS 141776-91-2

Name 1-bromomethyl-3,5-difluoro-benzene

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Basic Information

Synonyms: 1-bromomethyl-3,5-difluoro-benzene ±-bromo-3,5-difluorotoluene alpha-bromo-3,5-difluorotoluene à-bromo-3,5-difluorotoluene α-bromo-3,5-difluorotoluene 3,5-difluorobenzylbromide98% 2-benzyloxy-5-formylphenylboronicacid

Molecular Formula: C7H5BrF2

Molecular Weight: 207.02

MDL Number: MFCD00010304

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

3,5-Difluorobenzyl bromide is an organic compound characterized by a benzyl bromide core substituted with two fluorine atoms at the meta positions. It is a versatile and valuable building block in synthetic organic chemistry, primarily due to the reactivity of the benzylic bromide group, which readily undergoes nucleophilic substitution reactions such as alkylation, amination, and etherification. Its primary application is as a key intermediate in the synthesis of various pharmaceuticals and bioactive molecules. The presence of the difluorobenzyl moiety is particularly important in medicinal chemistry, as fluorine atoms are often introduced to modulate the lipophilicity, metabolic stability, and binding affinity of drug candidates. This compound is frequently employed in the construction of active pharmaceutical ingredients (APIs) and complex molecular scaffolds. As a reactive halide, it is a common starting material for the preparation of other functionalized derivatives, including 3,5-difluorobenzylamines, ethers, and organometallic reagents. It is typically handled with care under inert atmosphere due to its sensitivity to moisture and potential lachrymatory properties.

Physical Properties

Boiling Point: 65 °C/4.5 mmHg(lit.)

Flash Point: 82 °C

Density: 1.6 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.521(lit.)

Safety Information

Packing Level: II

Hazard Category: 8

Transport Codes: 3265

Analytical Data

Appearance: Colorless to light yellow liquid