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    148254-32-4

    Catalog No. EBD2076794

    CAS 148254-32-4

    Name 5-Bromo-2-chloro-4-fluorophenol

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    Basic Information

    Synonyms: 5-Bromo-2-chloro-4-fluorophenol 5-Bromo-2-chloro-4-fluoro-phenol phenol,5-bromo-2-chloro-4-fluoro- 5-broMo-2-chloro-4-fluorphenol

    Molecular Formula: C6H3BrClFO

    Molecular Weight: 225.44

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

    Product Description:
    5-Bromo-2-chloro-4-fluorophenol is an organic compound characterized by a phenol core substituted with bromo, chloro, and fluoro groups at the 5, 2, and 4 positions, respectively. It is a halogenated phenol derivative, typically appearing as a solid. This compound is primarily valued as a versatile and advanced synthetic building block in organic chemistry. Its main application lies in pharmaceutical research and development, where it serves as a key intermediate for constructing more complex molecules. The presence of multiple halogen atoms (Br, Cl, F) provides distinct reactive sites for various cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitutions. This makes it particularly useful for synthesizing drug candidates, especially those containing a multi-halogenated aromatic scaffold, which is common in agrochemicals and active pharmaceutical ingredients (APIs). As a halogenated phenol, it requires careful handling due to potential toxicity and irritant properties. Standard laboratory safety protocols for handling halogenated aromatic compounds should be followed.
    Physical Properties

    Storage: −20°C

    mg g kg ml l t