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    1620-75-3

    Catalog No. EBD53731

    CAS 1620-75-3

    Name 6-Methylpicolinonitrile

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    Basic Information

    Synonyms: 6-methyl-pyridine-2-carbonitrile 6-methylpicolinonitrile 2-cyano-6-methylpyridine 2-cyano-5-methlypyridine 6-methyl-2-pyridinecarbonitrile 2-cyano-6-methylpyridine,6-methylpicolinonitrile 2-cyano-6-methylpyridine/6-methyl-2-pyridinecarbonitrile 6-methylpyridine-2-carbonitrile

    Molecular Formula: C7H6N2

    Molecular Weight: 118.14

    MDL Number: MFCD00190586

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Cyano Compounds

    Product Description:
    6-Methylpyridine-2-carbonitrile is a heterocyclic organic compound featuring a pyridine ring substituted with a methyl group at the 6-position and a cyano group at the 2-position. It serves as a versatile and valuable building block in organic synthesis, particularly in the pharmaceutical industry. Its primary application is as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). The cyano group can be readily transformed into other functional groups such as carboxylic acids, amides, or tetrazoles, which are common pharmacophores. The pyridine core itself is a privileged scaffold found in numerous drugs. This compound is specifically cited in patent literature for the preparation of kinase inhibitors and other therapeutic agents targeting various diseases. As a bifunctional synthon containing both a heterocyclic aromatic system and a reactive nitrile, it is widely used in medicinal chemistry research for constructing complex molecular architectures. Its utility extends beyond pharmaceuticals into agrochemical and material science research, though its most significant and documented use remains in drug discovery and development.
    Physical Properties

    Melting Point: 70-74 °C(lit.)

    Boiling Point: 0°C

    Flash Point: 0°C

    Density: 1.08 g/cm3

    mg g kg ml l t