ZOSUQUIDAR TRIHYSROCHLORIDE, CAS No. 167465-36-3

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167465-36-3

Catalog No. EBD2202360

CAS 167465-36-3

Name ZOSUQUIDAR TRIHYSROCHLORIDE

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Basic Information

Synonyms: 1-Piperazineethanol,4-[(1aα,6α,10bα)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-,hydrochloride ZOSUQUIDARTRIHYSROCHLORIDE ly335979,rs33295-198 zosuquidartrihydrochloride rs33295-198 1-{4-[(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-olhydrochloride

Molecular Formula: C32H34Cl3F2N3O2

Molecular Weight: 636.99

Categories: Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

Zosuquidar trihydrochloride is a third-generation, potent, and selective inhibitor of P-glycoprotein (P-gp), an ATP-binding cassette (ABC) transporter. It is a quinoline derivative that functions as a multidrug resistance (MDR) reversal agent by binding to and inhibiting the drug efflux activity of P-gp, thereby increasing the intracellular concentration and efficacy of co-administered chemotherapeutic agents. Its primary application is in oncology research and clinical development to overcome P-gp-mediated multidrug resistance in various cancers, including breast cancer, leukemia, and ovarian cancer. It has been investigated in combination with chemotherapeutics like paclitaxel, doxorubicin, and vinblastine to enhance their antitumor activity. While not a standard chemotherapy drug itself, it is classified as an investigational drug substance (API) for its direct pharmacological role in modulating cancer therapy. Its development highlights the strategy of targeting resistance mechanisms to improve existing cancer treatments.

Physical Properties

Boiling Point: 690.5 °C at 760 mmHg

Flash Point: 371.4 °C