4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester, CAS No. 170911-92-9

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170911-92-9

Catalog No. EBD36076

CAS 170911-92-9

Name 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester

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Basic Information

Synonyms: TERT-BUTYL4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLATE 1-BOC-4-(4'-AMINOPHENYL)PIPERAZINE 1-(4-AMINO-PHENYL)-PIPERAZINE-4-CARBOXYLICACIDTERT-BUTYLESTER 4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLICACIDTERT-BUTYLESTER,95+% 4-(4-Boc-piperazin-1-yl)aniline 1-piperazinecarboxylicacid,4-(4-aminophenyl)-,1,1-dimethylethylester 4-(4-aminophenyl)piperazine,n1-bocprotected (R)-N-BOC-Allylglycine (R)-N-tert-Butoxycarbonyl-2-amino-4-pentenoicacid 4-(4-Aminophenyl)piperazine-1-carboxylicacidtert-butylester

Molecular Formula: C15H23N3O2

Molecular Weight: 277.36

MDL Number: MFCD04115065

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester is a white to off-white crystalline powder with a molecular formula of C15H23N3O2. It is a Boc-protected derivative featuring both a primary aromatic amine and a tertiary amine within a piperazine ring. This bifunctional structure makes it a versatile and valuable building block in organic synthesis. This compound is primarily employed as a key pharmaceutical intermediate. Its aromatic amine group allows for further functionalization, such as amide bond formation or reductive amination, while the Boc-protected piperazine nitrogen serves as a masked secondary amine. It has been reported in the synthesis of various biologically active molecules, including kinase inhibitors and compounds targeting the central nervous system. The Boc group provides orthogonal protection, facilitating selective reactions and subsequent deprotection under mild acidic conditions. As a bifunctional amine synthon, it is widely used in medicinal chemistry research for constructing compound libraries and exploring structure-activity relationships. Its stability under basic conditions and compatibility with common coupling reagents enhance its utility in multi-step synthetic routes.

Physical Properties

Boiling Point: 441.139 °C at 760 mmHg

Flash Point: 220.593 °C

Density: 1.145 g/cm3