2-[2-(diethylamino)ethoxy]ethyl 2-phenylbutanoate; 2-hydroxypropane-1,2,3-tricarboxylic acid, CAS No. 18109-81-4

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18109-81-4

Catalog No. EBD57366

CAS 18109-81-4

Name 2-[2-(diethylamino)ethoxy]ethyl 2-phenylbutanoate; 2-hydroxypropane-1,2,3-tricarboxylic acid

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Basic Information

Synonyms: Butamiratecitrate 18109-81-4 benzeneaceticacid,alpha-ethyl-,2-[2-(diethylamino)ethoxy]ethylester,2-hydroxy-1,2,3-propanetricarboxylate(1:1)(salt) Pertix 2-[2-(diethylamino)ethoxy]ethyl2-phenylbutanoate2-hydroxypropane-1,2,3-tricarboxylate(1:1) citricacid 2-hydroxypropane-1,2,3-tricarboxylicacid

Molecular Formula: C24H37NO10

Molecular Weight: 499.55

MDL Number: MFCD00315222

Categories: Medicinal Chemistry > APIs and Their Salts > Respiratory Drugs Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates

Product Description:

Butamirate citrate is a centrally acting antitussive agent, chemically known as 2-[2-(diethylamino)ethoxy]ethyl 2-phenylbutanoate citrate. It is the citrate salt of butamirate, a non-narcotic compound. The drug is typically administered as a syrup or oral solution. Its primary therapeutic application is in the symptomatic treatment of cough, particularly dry, non-productive cough associated with conditions such as bronchitis, tracheitis, and pharyngitis. Butamirate citrate acts by suppressing the cough reflex at the level of the cough center in the medulla oblongata. It is considered to have a good safety profile with a low incidence of side effects like drowsiness compared to some older antitussives. As an active pharmaceutical ingredient (API), it is formulated into various finished dosage forms. The compound itself, or its free base butamirate, can also serve as a key intermediate in pharmaceutical synthesis and research focused on respiratory therapeutics.

Physical Properties

Melting Point: 66-68 °C

Boiling Point: 394.4 °C at 760 mmHg

Flash Point: 192.3 °C

Analytical Data

Appearance: White solid