3-Bromo-4-oxopiperidine-1-carboxylic acid tert-butyl ester, CAS No. 188869-05-8

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188869-05-8

Catalog No. EBD53236

CAS 188869-05-8

Name 3-Bromo-4-oxopiperidine-1-carboxylic acid tert-butyl ester

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Basic Information

Synonyms: tert-butyl3-bromo-4-oxopiperidine-1-carboxylate 3-bromo-4-oxo-piperidine-1-carboxylicacidtert-butylester buttpark15357-01 n-boc-3-bromo-4-oxopiperidine 1-piperidinecarboxylicacid,3-bromo-4-oxo-,1,1-dimethylethylester 1-tert-butoxycarbonyl-3-bromo-4-oxopiperidine 1-tert-butyloxycarbonyl-3-bromo-4-oxopiperidine BUTTPARK153\57-01 1-Boc-3-bromo-4-oxopiperidine 3-Bromo-4-oxopiperidine-1-carboxylicacidtert-butylester

Molecular Formula: C10H16BrNO3

Molecular Weight: 278.14

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones

Product Description:

3-Bromo-4-oxopiperidine-1-carboxylic acid tert-butyl ester is a heterocyclic building block featuring a piperidine ring with a bromine atom at the 3-position, a ketone at the 4-position, and a tert-butoxycarbonyl (Boc) protecting group on the nitrogen. This compound is primarily utilized as a key intermediate in the synthesis of pharmaceutical agents, particularly in the development of kinase inhibitors and other bioactive molecules targeting neurological and oncological pathways. The bromine substituent enables further functionalization via cross-coupling reactions (e.g., Suzuki or Buchwald-Hartwig), while the ketone group allows for reductive amination or nucleophilic addition. Additionally, it serves as a versatile synthetic building block in organic chemistry for constructing complex piperidine derivatives, making it valuable in both medicinal chemistry and general synthetic research.

Physical Properties

Boiling Point: 333.3 °C at 760 mmHg

Flash Point: 155.4 °C

Density: 1.422 g/cm3

Solubility: at 25 deg C (mg/L): 1252

Analytical Data

Appearance: Light yellow solid