Bis(2-methoxyethyl)aminosulfur trifluoride, CAS No. 202289-38-1

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202289-38-1

Catalog No. EBD51707

CAS 202289-38-1

Name Bis(2-methoxyethyl)aminosulfur trifluoride

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Basic Information

Synonyms: Bis(2-methoxyethyl)aminosulfur trifluoride (bis(2-methoxyethyl)amino)sulfurtrifluoride Bis(2-methoxyethyl)aminosulfurtrifluoride Deoxo-Fluor [Bis(2-methoxyethyl)amino]sulfurtrifluoride Deoxofluor(BAST) Bis(2-methoxyethyl)aminosulphurtrifluoride 2-methoxy-N-(2-methoxyethyl)-N-(trifluoro-lambda~4~-sulfanyl)ethanamine BAST DEOXO-FLUOR(R)

Molecular Formula: C6H14F3NO2S

Molecular Weight: 221.24

MDL Number: MFCD01321415

Categories: Synthetic Chemistry > Basic Synthetic Reagents > Halogenation Reagents Synthetic Chemistry > Organic Building Blocks > Phosphorus Compounds

Product Description:

Bis(2-methoxyethyl)aminosulfur trifluoride is a specialized fluorinating reagent. It is a liquid, sulfur-based compound known for its role as a deoxofluorination agent, effectively converting alcohols, aldehydes, and ketones into their corresponding alkyl fluorides, gem-difluorides, and trifluoromethyl groups, respectively. Its primary application is in synthetic organic chemistry, particularly in the late-stage fluorination of complex molecules, including pharmaceuticals and agrochemicals. Compared to other reagents like DAST or Deoxo-Fluor, it is often noted for its improved thermal stability and safety profile, making it a valuable tool for introducing fluorine atoms, which can significantly alter a compound's metabolic stability, lipophilicity, and bioavailability. This reagent is a staple in the toolkit of medicinal and process chemists for constructing C-F bonds. It is commercially available and requires careful handling under inert atmosphere due to its moisture sensitivity and potential to release hazardous hydrogen fluoride upon decomposition.

Physical Properties

Boiling Point: >80°C

Flash Point: <10 °C

Density: 1.03-1.05 g/mL at 20 °C

Storage: 2-8°C

Safety Information

Packing Level: II

Hazard Category: 8(6.1)(3)

Transport Codes: 3286

Analytical Data

Appearance: Dark yellow-orange liquid