methyl 1-aminocyclobutanecarboxylate, CAS No. 215597-35-6

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

215597-35-6

Catalog No. EBD32653

CAS 215597-35-6

Name methyl 1-aminocyclobutanecarboxylate

Get Quote

Basic Information

Synonyms: Cyclobutanecarboxylicacid,1-amino-,methylester,hydrochloride(1:1) cyclobutanecarboxylicacid,1-amino-,methylesterhydrochloride methyl1-aminocyclobutane-1-carboxylatehydrochloride methyl1-aminocyclobutanecarboxylate 1-amino-cyclobutanecarboxylicacidmethylester 1-aminocyclobutylcarboxylicacidmethylester methyl1-amino-cyclobutanecarboxylate

Molecular Formula: C6H11NO2

Molecular Weight: 129.16

MDL Number: MFCD04115288

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

1-Aminocyclobutanecarboxylic acid methyl ester is a chemical compound featuring a cyclobutane ring substituted with both an amino group and a methyl ester group. This structure makes it a constrained, non-proteinogenic amino acid derivative, which is a valuable building block in medicinal chemistry. Its primary application is as a key intermediate in the synthesis of pharmaceutical compounds. It is notably used in the preparation of novel inhibitors, such as dipeptidyl peptidase IV (DPP-4) inhibitors for the treatment of type 2 diabetes. The rigid cyclobutane scaffold is employed to induce specific conformational constraints in target molecules, potentially enhancing potency and metabolic stability. As a bifunctional synthon containing both a nucleophilic amine and an electrophilic ester, it is also a versatile reagent in organic synthesis for constructing complex molecules with cyclobutane motifs. It is typically handled under inert atmosphere due to the reactivity of the amino group.

Physical Properties

Boiling Point: 162.311 °C at 760 mmHg

Flash Point: 36.303 °C

Density: 1.127 g/cm3