Lithium amidosulfonate is an inorganic salt with the formula LiNH₂SO₃. It is a white crystalline solid that is soluble in water. Structurally, it consists of a lithium cation paired with an amidosulfonate anion (NH₂SO₃⁻), which contains both an amino group and a sulfonate group. This compound is primarily utilized as a specialized reagent in synthetic chemistry. Its key application is as a source of the amidosulfonate anion for the synthesis of sulfamates and related compounds. It can act as a nucleophile in reactions with alkyl halides or epoxides to introduce the -NH-SO₃⁻ moiety. Additionally, it serves as a precursor for generating other metal amidosulfonates. Lithium amidosulfonate is considered a strong base due to the presence of the amide-like nitrogen. It must be handled with care under inert atmosphere conditions (e.g., nitrogen or argon) as it is moisture-sensitive and may react vigorously with water and acids.