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    21943-13-5

    Catalog No. EBD12156

    CAS 21943-13-5

    Name 2-Amino-5-bromo-3-chloropyrazine

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    Basic Information

    Synonyms: 5-Bromo-3-chloropyrazin-2-amine 2-pyrazinamine,5-bromo-3-chloro- 5-Bromo-3-chloro-pyrazin-2-ylamine 2-Amino-5-bromo-3-chloropyrazine

    Molecular Formula: C4H3BrClN3

    Molecular Weight: 208.44

    MDL Number: MFCD11109828

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    5-Bromo-3-chloropyrazin-2-amine is a halogenated heterocyclic compound featuring both bromine and chlorine substituents on a pyrazine ring, along with an amine functional group. This specific substitution pattern makes it a versatile and valuable synthetic intermediate. Its primary application is in pharmaceutical research and development, where it serves as a key building block for the synthesis of various drug candidates. The presence of multiple halogen atoms allows for selective cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions, enabling the construction of complex molecules. It is particularly relevant in the synthesis of kinase inhibitors and other biologically active heterocyclic compounds targeting various therapeutic areas. Due to its well-defined reactive sites (bromine, chlorine, and amine), it is also widely utilized as a specialized organic synthesis block in academic and industrial laboratories for constructing pyrazine-based scaffolds.
    Physical Properties

    Boiling Point: 271.288 °C at 760 mmHg

    Flash Point: 117.871 °C

    Density: 1.961 g/cm3

    mg g kg ml l t