4-Fluorothiobenzamide, CAS No. 22179-72-2

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22179-72-2

Catalog No. EBD1938

CAS 22179-72-2

Name 4-Fluorothiobenzamide

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Basic Information

Synonyms: (S)-(+)-2-(3-Benzoylphenyl)propionicacid 4-Fluorothiobenzamide 244-820-9 4-Fluorobenzenecarbothioamide Benzenecarbothioamide,4-fluoro- buttpark62\07-42 4-fluorobenzothioamide 4-fluoro-1-benzenecarbothioamide

Molecular Formula: C7H6FNS

Molecular Weight: 155.19

MDL Number: MFCD01313285

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Sulfides and Thioethers

Product Description:

4-Fluorothiobenzamide is an organic compound featuring a benzamide core structure substituted with a fluorine atom at the para-position and a thioamide (-C(=S)NH2) functional group. This structure combines the electron-withdrawing properties of fluorine with the versatile reactivity of the thioamide moiety. This compound serves as a key synthetic intermediate in medicinal chemistry. Its primary application is in the synthesis of various heterocyclic compounds, particularly thiazole and thiadiazole derivatives. These heterocyclic scaffolds are prevalent in the development of pharmacologically active molecules, including potential antibacterial, antifungal, and anticancer agents. The fluorine atom can enhance metabolic stability and influence the binding affinity of the final drug candidates. As a bifunctional building block, it is also utilized in organic synthesis research for constructing more complex sulfur-containing molecules. Standard safety precautions for handling laboratory chemicals should be observed.

Physical Properties

Melting Point: 140-145 °C

Boiling Point: 239.5 °C at 760 mmHg

Flash Point: 98.6 °C

Density: 1.29 g/cm3

Storage: Refrigerator (+4°C)

Safety Information

Packing Level:

Hazard Category:

Transport Codes: 3335

Analytical Data

Appearance: light yellow solid