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    22766-68-3

    Catalog No. EBD276336

    CAS 22766-68-3

    Name 1-aza-bicyclo[2.2.2]octane-4-carboxylic acid ethyl ester

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    Basic Information

    Synonyms: Chinuclidin-4-carbonsaeure-aethylester ethyl1-aza-bicyclo[2.2.2]octane-4-carboxylate ethyl1-azabicyclo[2.2.2]octane-4-carboxylate ethyl-1-azabicyclo[2.2.2]octane-4-carboxylate 4-carbethoxyquinuclidine 1-Azabicyclo[2.2.2]octane-4-carboxylicacid,ethylester Ethylquinuclidine-4-carboxylate 1-aza-bicyclo[2.2.2]octane-4-carboxylicacidethylester quinuclidine-4-carboxylicacidethylester

    Molecular Formula: C10H17NO2

    Molecular Weight: 183.25

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    Ethyl quinuclidine-4-carboxylate is an organic compound featuring a quinuclidine core structure esterified with an ethyl group. The quinuclidine moiety is a rigid, bicyclic tertiary amine, which imparts significant steric and electronic properties to the molecule. This compound serves as a crucial synthetic intermediate in medicinal chemistry. Its primary application is in the synthesis of muscarinic acetylcholine receptor antagonists. Specifically, it is a key building block for the production of glycopyrronium bromide, a quaternary ammonium anticholinergic agent used in the treatment of chronic obstructive pulmonary disease (COPD) and as a preoperative medication to reduce secretions. The ester group provides a handle for further chemical modifications, making it a versatile precursor. As a heterocyclic amine derivative, it is also utilized as a specialized organic synthesis building block in the development of other pharmacologically active compounds that require a rigid, nitrogen-containing scaffold.
    Physical Properties
    mg g kg ml l t