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    24485-01-6

    Catalog No. EBD4272

    CAS 24485-01-6

    Name 5,7-Dichloro-1H-imidazo[4,5-b]pyridine

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    Basic Information

    Synonyms: 5,7-Dichloro-1H-imidazo[4,5-b]pyridine 5,7-dichloro-7aH-imidazo[4,5-b]pyridine 1H-imidazo[4,5-b]pyridine,5,7-dichloro- 3H-Imidazo[4,5-b]pyridine,5,7-dichloro- 5,7-Dichloro-3H-imidazo[4,5-b]pyridine

    Molecular Formula: C6H3Cl2N3

    Molecular Weight: 188.01

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    5,7-Dichloro-1H-imidazo[4,5-b]pyridine is a fused heterocyclic compound featuring an imidazole ring fused to a pyridine ring, with chlorine substituents at the 5 and 7 positions. This specific substitution pattern makes it a valuable and versatile building block in medicinal chemistry. Its primary application is as a key synthetic intermediate in the development of pharmaceutical compounds. The dichloroimidazopyridine scaffold serves as a core structure for constructing molecules with potential biological activity. It is notably utilized in the synthesis of kinase inhibitors, which are a major class of targeted therapeutics for diseases such as cancer and inflammatory disorders. The chlorine atoms provide handles for further functionalization via cross-coupling reactions, allowing for the rapid generation of diverse compound libraries for drug discovery. While its main use is clearly defined in pharmaceutical research, its well-defined structure and reactivity also position it as a specialized organic synthesis building block for constructing complex nitrogen-containing heterocycles in academic and industrial settings.
    Physical Properties

    Boiling Point: 416.867 °C at 760 mmHg

    Flash Point: 238.425 °C

    Density: 1.675 g/cm3

    mg g kg ml l t