Fosfomycin calcium, CAS No. 26016-98-8

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26016-98-8

Catalog No. EBD6503

CAS 26016-98-8

Name Fosfomycin calcium

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Basic Information

Synonyms: Fosfomycincalciumsalt Phosphomycincalciumsalt phosphomycincalcium FosfomycinCalcium (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonicacid [(2R,3S)-3-Methyloxiranyl]phosphonicacidcalciumsalt calcium[(2R,3S)-3-methyloxiran-2-yl]phosphonate calcium[(2S,3R)-3-methyloxiran-2-yl]phosphonate calcium(3-methyloxiran-2-yl)phosphonate Phosphonicacid,(3-methyloxiranyl)-,calciumsalt(1:1),(2R-trans)- calcium[(2S,3R)-3-methylox (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonicacidcalciumsalt(1:1)

Molecular Formula: C3H5CaO4P

Molecular Weight: 176.12

MDL Number: MFCD00070095

Categories: Medicinal Chemistry > APIs and Their Salts > Anti-infectives Medicinal Chemistry > Pharmaceutical Excipients > Other Pharmaceutical Excipients

Product Description:

Fosfomycin calcium is the calcium salt of fosfomycin, a broad-spectrum bactericidal antibiotic. It is a structural analog of phosphoenolpyruvate and acts by irreversibly inhibiting the enzyme MurA (UDP-N-acetylglucosamine enolpyruvyl transferase), which is essential for the first committed step in bacterial cell wall synthesis. This unique mechanism of action makes it effective against a range of Gram-positive and Gram-negative bacteria, including some multidrug-resistant strains. Primarily, fosfomycin calcium is used as an active pharmaceutical ingredient (API) in oral formulations for the treatment of uncomplicated urinary tract infections (UTIs), particularly those caused by Escherichia coli and Enterococcus faecalis. Its high urinary concentration and good safety profile make it a valuable therapeutic option. Beyond its role as an API, calcium fosfomycin can also function as a source of calcium in certain pharmaceutical preparations, falling under the category of excipients with specific mineral-providing functions.

Physical Properties

Boiling Point: 342.7 °C at 760 mmHg

Flash Point: 161 °C

Solubility: Slightly soluble in water, in almost insoluble in methanol, insoluble in acetone, chloroform, ethyl ether and benzene

Storage: 2-8°C

Analytical Data

Appearance: White crystal powder, tasteless