Imidazole, CAS No. 288-32-4

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288-32-4

Catalog No. EBD2202689

CAS 288-32-4

Name Imidazole

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Basic Information

Synonyms: Glyoxaline ImidazoleGlyoxaline Imidazole,ULTROLGrade 1,3-diazole IMZ Methanimidamide,N,N-1,2-ethenediyl- 1H-Imidazole(9CI)

Molecular Formula: C3H4N2

Molecular Weight: 68.08

MDL Number: MFCD00005183

Categories: Functional Chemicals > Consumer & Industrial Chemicals > Industrial Auxiliaries

Product Description:

Imidazole is a five-membered heterocyclic compound containing two nitrogen atoms at positions 1 and 3. It is a planar, aromatic molecule with a molecular formula of C_H_N_ and a molecular weight of 68.08 g/mol. The compound exists as a white to off-white crystalline solid at room temperature and is highly soluble in water and polar organic solvents. As a fundamental heterocyclic building block, imidazole is extensively utilized in the pharmaceutical industry for the synthesis of numerous active pharmaceutical ingredients (APIs), including antifungal agents (e.g., ketoconazole, miconazole), antiprotozoal drugs (e.g., metronidazole), and antihypertensive agents. It also serves as a key intermediate in the production of agrochemicals and corrosion inhibitors. In synthetic chemistry, imidazole functions as a versatile reagent, acting as a nucleophilic catalyst, a buffer component, and a precursor for ionic liquids and N-heterocyclic carbenes (NHCs). Its amphoteric nature (pKa ~7.0) makes it an effective pH buffer in biological and chemical systems.

Physical Properties

Melting Point: 88-91 °C(lit.)

Boiling Point: 256 °C(lit.)

Flash Point: 145 °C

Density: 1.01 g/mL at 20 °C

Solubility: H2O: 0.1 M at 20 °C, clear, colorless

Refractivity: 1.4801

Storage: 2-8°C

Safety Information

Packing Level: II

Hazard Category: 8

Transport Codes: 3263