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    31181-79-0

    Catalog No. EBD209696

    CAS 31181-79-0

    Name (3-FLUOROPYRID-2-YL)METHANOL

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    Basic Information

    Synonyms: (3-FLUOROPYRID-2-YL)METHANOL 2-pyridinemethanol,3-fluoro- 3-Fluoro-2-(hydroxymethyl)pyridine (3-fluoro-2-pyridyl)methanol (3-Fluoropyridin-2-yl)methanol

    Molecular Formula: C6H6FNO

    Molecular Weight: 127.04

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    2-(Hydroxymethyl)-3-fluoropyridine is a heterocyclic organic compound featuring a pyridine ring substituted with a hydroxymethyl group at the 2-position and a fluorine atom at the 3-position. This structure combines a reactive alcohol functionality with a fluorine substituent on an aromatic nitrogen heterocycle, making it a versatile bifunctional building block. Its primary application is as a key pharmaceutical intermediate. The presence of the fluorine atom, a common bioisostere, and the hydroxymethyl group, which can be further functionalized, makes it valuable in the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) drugs and other bioactive molecules. The pyridine core is a privileged scaffold in medicinal chemistry. As a synthetic building block, it serves as a precursor for more complex fluorinated pyridine derivatives. The hydroxymethyl group can undergo typical alcohol reactions (e.g., oxidation, esterification, etherification), while the fluorine atom can participate in various metal-catalyzed cross-coupling reactions, allowing for structural diversification in drug discovery and material science research.
    Physical Properties

    Storage: −20°C

    mg g kg ml l t