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    31252-42-3

    Catalog No. EBD47673

    CAS 31252-42-3

    Name 4 - Benzylpiperidine

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    Basic Information

    Synonyms: 4-(Phenylmethyl)piperidine alpha-(4-piperidyl)toluene 4-benzyl-piperidine piperidine,4-(phenylmethyl)- 4-Benzylpiperidine 4-benzylpiperidinium

    Molecular Formula: C12H17N

    Molecular Weight: 175.27

    MDL Number: MFCD00006006

    Categories: Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    4-Benzylpiperidine is a heterocyclic organic compound featuring a piperidine ring substituted with a benzyl group at the 4-position. It is a colorless to pale yellow liquid with a molecular formula of C12H17N and a molecular weight of 175.27 g/mol. Structurally, it serves as a key building block in medicinal chemistry due to the presence of both a secondary amine and a benzyl moiety, which facilitate further functionalization. This compound is primarily utilized as an intermediate in the synthesis of various pharmaceuticals, particularly in the development of central nervous system (CNS) agents, including antipsychotics, antidepressants, and analgesics. The piperidine core is a privileged scaffold in drug discovery, and the benzyl substituent enhances lipophilicity and receptor binding affinity. It is also employed in the preparation of enzyme inhibitors and receptor modulators. As a versatile synthetic building block, 4-benzylpiperidine is widely used in organic synthesis for constructing more complex molecules via N-alkylation, acylation, or reductive amination reactions. It is typically handled under standard laboratory conditions and should be stored in a cool, dry place away from strong oxidizing agents. Its commercial availability and reactivity make it a valuable reagent in both academic research and industrial pharmaceutical production.
    Physical Properties

    Melting Point: 6-7 °C(lit.)

    Boiling Point: 279 °C(lit.)

    Flash Point: 112 °C

    Density: 0.997 g/mL at 25 °C(lit.)

    Refractivity: n20/D 1.537(lit.)

    mg g kg ml l t