6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide, CAS No. 342417-01-0

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342417-01-0

Catalog No. EBD386206

CAS 342417-01-0

Name 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide

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Basic Information

Synonyms: 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide 4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide 6-(4-methyl-piperazin-1-yl)-4-o-tolyl-nicotinamide 6-(4-methylpiperazin-1-yl)-4-o-tolyl-nicotinamide 4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridine-3-carboxamide 4-(2-Methylphenyl)-6-(4-methylpiperazin-1-yl)nicotinamide 3-Pyridinecarboxamide,4-(2-Methylphenyl)-6-(4-Methyl-1-Piperazinyl)- NetupitantIntermediate-3 6-(4-methylpiperazin-1-yl)-4-o-tolylnicotinamide

Molecular Formula: C18H22N4O

Molecular Weight: 310.4

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents

Product Description:

The compound with CAS number 342417-01-0 is 6-(4-methylpiperazin-1-yl)-4-(2-methylphenyl)nicotinamide. It is a synthetic organic molecule featuring a nicotinamide core substituted with a 4-methylpiperazine group and a 2-methylphenyl group. This structure is characteristic of a heterocyclic intermediate. This compound is a key intermediate in the synthesis of the investigational anticancer drug **Tivozanib (AV-951)**. Tivozanib is a potent and selective small-molecule inhibitor of vascular endothelial growth factor receptor (VEGFR) tyrosine kinases, specifically VEGFR-1, -2, and -3. It was developed for the treatment of advanced renal cell carcinoma (RCC) and other solid tumors. The compound serves as a crucial building block in the final steps of the drug's synthetic pathway. As a pharmaceutical intermediate, its primary industrial application is confined to the production of the active pharmaceutical ingredient (API) Tivozanib. Handling requires standard laboratory safety precautions for organic compounds.

Physical Properties

Storage: −20°C