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    36052-27-4

    Catalog No. EBD28995

    CAS 36052-27-4

    Name Methyl 3-aminopyridine-2-carboxylate

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    Basic Information

    Synonyms: Methyl3-aminopicolinate 2-Pyridinecarboxylicacid,3-amino-,methylester 3-Aminopyridine-2-carboxylicacidmethylester Methyl3-aminopyridine-2-carboxylate

    Molecular Formula: C7H8N2O2

    Molecular Weight: 152.15

    MDL Number: MFCD08695602

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    Methyl 3-aminopyridine-2-carboxylate is an organic compound featuring a pyridine ring substituted with an amino group at the 3-position and a methyl ester at the 2-position. This structure makes it a versatile heterocyclic building block, particularly valuable in medicinal chemistry. Its primary and significant application is as a key pharmaceutical intermediate. It serves as a crucial precursor in the synthesis of various biologically active molecules, most notably in the development of kinase inhibitors. For instance, it is a fundamental starting material or intermediate in the synthesis of important drug candidates such as imatinib analogs and other tyrosine kinase inhibitors targeting cancer pathways. The amino and ester functionalities provide handles for further derivatization, enabling the construction of complex heterocyclic scaffolds central to modern drug discovery. While its dominant use is in pharmaceutical synthesis, its well-defined structure also qualifies it as a specialized organic synthesis building block for researchers constructing pyridine-containing compounds in other fields, such as materials science or agrochemical research.
    Physical Properties

    Boiling Point: 317.293 °C at 760 mmHg

    Flash Point: 145.694 °C

    Density: 1.239 g/cm3

    mg g kg ml l t