Ethyl malonyl chloride, CAS No. 36239-09-5

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36239-09-5

Catalog No. EBD50813

CAS 36239-09-5

Name Ethyl malonyl chloride

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Basic Information

Synonyms: Malonicacidmonoethylesterchloride Ethylmalonylmonochloride 3-chloro-3-oxo-propanoicaciethylester Propanoicacid,3-chloro-3-oxo-,ethylester auroraka-3051 (chloroformyl)aceticacidethylester ethyl2-(chlorocarbonyl)acetate ethanylmalonylchloride Ethylmalonoylchloride ethylpropanedioyldichloride Ethylmalonylchloride

Molecular Formula: C5H7ClO3

Molecular Weight: 150.56

MDL Number: MFCD00000736

Categories: Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Synthetic Chemistry > Basic Synthetic Reagents > Other Basic Synthetic Reagents

Product Description:

Ethyl malonyl chloride is a reactive acyl chloride derivative of malonic acid monoethyl ester. It is a colorless to pale yellow liquid with a pungent odor, sensitive to moisture and air. Its molecular formula is C5H7ClO3. This compound is a versatile and important reagent in organic synthesis, primarily used as a building block for the introduction of the malonate moiety. It is a key intermediate in the synthesis of various heterocyclic compounds, such as pyrimidines and pyridines. It is also employed in the preparation of pharmaceuticals, agrochemicals, and other fine chemicals through acylation reactions, where it acts as an efficient electrophile. Due to its high reactivity with nucleophiles (e.g., water, alcohols, amines), it must be handled under anhydrous conditions, typically using inert atmospheres like nitrogen or argon. It is a lachrymator and corrosive substance, requiring appropriate personal protective equipment during use.

Physical Properties

Boiling Point: 79-80 °C/25 mmHg(lit.)

Flash Point: 64 °C

Density: 1.176 g/mL at 25 °C(lit.)

Solubility: REACTS

Refractivity: n20/D 1.429(lit.)

Storage: 2-8°C

Safety Information

Packing Level: III

Hazard Category: 8

Transport Codes: 3265