(2-fluoropyridin-4-yl)-boronic acid, CAS No. 401815-98-3

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401815-98-3

Catalog No. EBD28596

CAS 401815-98-3

Name (2-fluoropyridin-4-yl)-boronic acid

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Basic Information

Synonyms: 2-Fluoropyridine-4-boronicacid (2-Fluoropyridin-4-yl)boronicacid Boronicacid,B-(2-fluoro-4-pyridinyl)- 2-Fluoropyridine-BoronicAcid 2-fluoropyridin-4-ylboronicacid (2-fluoropyridin-4-yl)-boronicacid 2-fluoro-4-pyridinylboronicacid 2-fluoro-4-pyridylboronicacid (2-fluoro-pyridin-4-yl)-boronicacid 2-Fluoropyridine-4-boronic acid

Molecular Formula: C5H5BFNO2

Molecular Weight: 140.91

MDL Number: MFCD04112534

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

Product Description:

2-Fluoropyridine-4-boronic acid is an organoboron compound featuring a pyridine ring substituted with a fluorine atom at the 2-position and a boronic acid group at the 4-position. This structure combines the electron-withdrawing and steric influence of the fluorine atom with the versatile reactivity of the boronic acid functional group. Its primary and most significant application is as a key pharmaceutical intermediate. The boronic acid moiety enables crucial Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing biaryl and heterobiaryl linkages. The 2-fluoropyridine scaffold is a privileged structure in drug discovery, often found in active pharmaceutical ingredients (APIs) targeting various diseases, including central nervous system disorders and oncology. This compound serves as a critical building block for synthesizing these complex drug candidates. As an organoboron reagent, it is also widely utilized in general synthetic chemistry as a versatile coupling partner. It is commercially available from major chemical suppliers for research and development purposes. Standard precautions for handling boronic acids and fluorinated compounds should be observed.

Physical Properties

Boiling Point: 326.8 °C at 760 mmHg

Flash Point: 151.5 °C

Density: 1.34 g/cm3

Analytical Data

Appearance: white solid