1H-Pyrazole-1-carboxamidine hydrochloride, CAS No. 4023-02-3

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4023-02-3

Catalog No. EBD28135

CAS 4023-02-3

Name 1H-Pyrazole-1-carboxamidine hydrochloride

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Basic Information

Synonyms: 1H-pyrazole-1-carboxamidinemonohydro-chloride 1H-Pyrazole-1-carboxamidinemonohydrochloride 1-Amidinopyrazolemonohydrochloride 1H-Pyrazole-1-carboxamidinehydrochloride ZanamivirIntermediates 1H-pyrazole-1-carboxamidehydrochloride(1:1) 1H-Pyrazole-1-carboximidamidehydrochloride 1-Amidinopyrazolehydrochloride Praxadine

Molecular Formula: C4H7ClN4

Molecular Weight: 146.58

MDL Number: MFCD00210087

Categories: Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Organic Building Blocks > Special Functional Group Blocks

Product Description:

1H-Pyrazole-1-carboxamidine hydrochloride is a heterocyclic compound featuring a pyrazole ring substituted with a carboxamidine group, presented as a hydrochloride salt. Its molecular formula is C4H7ClN4, and it is commonly used as a guanidinylation reagent in organic synthesis. This compound serves as a key intermediate in the synthesis of pharmaceutical agents, particularly for introducing amidine or guanidine moieties into drug molecules. It is widely employed in the preparation of kinase inhibitors, antiviral compounds, and other bioactive heterocycles. The pyrazole scaffold itself is a privileged structure in medicinal chemistry, appearing in numerous approved drugs. As a versatile synthetic building block, it functions as an amine equivalent in various coupling reactions, enabling the construction of complex nitrogen-containing frameworks. Its hydrochloride salt form ensures stability and ease of handling in laboratory and industrial settings.

Physical Properties

Melting Point: 167-170 °C(lit.)

Solubility: Soluble in water

Analytical Data

Appearance: white to light yellow crystals or crystalline