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    406933-21-9

    Catalog No. EBD14611

    CAS 406933-21-9

    Name 3-(Trifluoromethyl)picolinonitrile

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    Basic Information

    Synonyms: 2-Cyano-3-Trifluoromethylpyridine 3-(trifluoromethyl)pyridine-2-carbonitrile

    Molecular Formula: C7H3F3N2

    Molecular Weight: 172.11

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Cyano Compounds

    Product Description:
    2-Cyano-3-(trifluoromethyl)pyridine is a heterocyclic organic compound featuring a pyridine ring substituted with a cyano group at the 2-position and a trifluoromethyl group at the 3-position. It is a versatile and valuable building block in medicinal chemistry and organic synthesis. Its primary application is as a key intermediate in the synthesis of pharmaceutical compounds. The presence of both the electron-withdrawing trifluoromethyl group and the reactive cyano group makes it a crucial precursor for constructing more complex heterocyclic systems, particularly those with potential biological activity. It is notably used in the research and development of kinase inhibitors and other small molecule drugs targeting various diseases. As a bifunctional synthon, it is employed in various coupling reactions and cyclization processes. The compound is typically handled as a solid and requires standard precautions for laboratory chemicals, including the use of personal protective equipment due to its potential toxicity and irritant properties.
    Physical Properties

    Boiling Point: 240.468 °C at 760 mmHg

    Flash Point: 99.232 °C

    Density: 1.373 g/cm3

    mg g kg ml l t