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    411235-57-9

    Catalog No. EBD27253

    CAS 411235-57-9

    Name Cyclopropylboronic acid

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    Basic Information

    Synonyms: Boronicacid,cyclopropyl- Cyclopropylboronicacidmonohydrate 4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]benzoicacid Cyclopropylboronicacid cyclopropylbronicacid cycloropylboronicacid boronicacid,cyclopropyl-(9ci) cyclopropylboronicacid,monohydrate

    Molecular Formula: C3H7BO2

    Molecular Weight: 85.9

    MDL Number: MFCD04038750

    Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

    Product Description:
    Cyclopropylboronic acid is an organoboron compound featuring a cyclopropyl group directly bonded to a boronic acid moiety. Its molecular formula is C_H_BO_, and it is typically a white to off-white solid. The compound is characterized by the strained three-membered cyclopropyl ring, which imparts unique reactivity and conformational rigidity. As a key building block in organic synthesis, cyclopropylboronic acid is widely utilized in Suzuki-Miyaura cross-coupling reactions to introduce the cyclopropyl group into complex molecules. This makes it an essential reagent for constructing pharmaceutical intermediates, agrochemicals, and functional materials. In medicinal chemistry, it serves as a versatile fragment for drug discovery, particularly in the synthesis of bioactive molecules where the cyclopropyl moiety can enhance metabolic stability and binding affinity. The compound is also employed in the preparation of cyclopropyl-substituted heterocycles and as a precursor for other boron-containing reagents. It is generally handled under inert atmosphere to prevent oxidation and should be stored in a cool, dry place. Its stability and reactivity make it a valuable tool in both academic research and industrial process development.
    Physical Properties

    Melting Point: 90-95 °C(lit.)

    Boiling Point: 205.1 °C at 760 mmHg

    Flash Point: 77.9 °C

    Density: 1.11 g/cm3

    Storage: −20°C

    Analytical Data

    Appearance: white powder

    mg g kg ml l t