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    41960-47-8

    Catalog No. EBD464164

    CAS 41960-47-8

    Name 2-Cyano-5-iodopyridine

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    Basic Information

    Synonyms: 2-Cyano-5-iodopyridine 5-iodopyridine-2-carbonitrile 2-Pyridinecarbonitrile,5-iodo- 5-Iodo-2-cyanopyridine 5-Iodo-2-pyridinecarbonitrile 5-Iodopicolinonitrile T6NJBCNEI

    Molecular Formula: C6H3IN2

    Molecular Weight: 230.01

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Cyano Compounds

    Product Description:
    2-Cyano-5-iodopyridine is a heterocyclic organic compound featuring both a cyano group and an iodine atom on a pyridine ring. This bifunctional structure makes it a versatile and valuable building block in synthetic organic chemistry. Its primary application is as a key intermediate in the synthesis of more complex molecules, particularly in pharmaceutical research. The iodine atom serves as an excellent site for cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira), allowing for the introduction of various aryl, alkenyl, or alkynyl groups. Simultaneously, the cyano group can be transformed into other functional groups such as carboxylic acids, amides, or tetrazoles, or serve as a directing group in metalation reactions. This dual reactivity enables the efficient construction of diverse compound libraries for drug discovery. The compound is commonly used in the synthesis of kinase inhibitors and other biologically active heterocycles. It is typically handled under inert atmosphere due to its sensitivity and should be stored away from light.
    Physical Properties

    Boiling Point: 314.3 °C at 760 mmHg

    Flash Point: 143.9 °C

    Density: 2.04 g/cm3

    mg g kg ml l t