1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone, CAS No. 43229-01-2

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

43229-01-2

Catalog No. EBD25478

CAS 43229-01-2

Name 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone

Get Quote

Basic Information

Synonyms: 2-Bromo-1-[3-nitro-4-(phenylmethoxy)phenyl]-ethanone 2-Bromo-1-[3-Nitro-4-(Phenylmethoxy)Phenyl]Ethanone 2-bromo-4'-benzyloxy-3'-nitroacetophenone 1-(4-Benzyloxy-3-nitro-phenyl)-2-bromo-ethanone 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone

Molecular Formula: C15H12BrNO4

Molecular Weight: 350.16

MDL Number: MFCD06797599

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone is a key synthetic intermediate in the production of Formoterol, a long-acting β2-adrenergic receptor agonist (LABA) used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Its structure features a benzyl-protected phenol, a nitro group, and a reactive bromoacetyl moiety, which are crucial functional handles for subsequent cyclization and amination steps in the synthetic route. This compound is specifically designed and utilized in the multi-step synthesis of Formoterol's active pharmaceutical ingredient (API). Its primary and almost exclusive industrial application is within pharmaceutical manufacturing processes. The bromoacetyl group is a common electrophile that facilitates the formation of the critical ethanolamine side chain and the oxime functionality present in the final drug molecule, making this intermediate indispensable for constructing Formoterol's complex pharmacophore.

Physical Properties

Boiling Point: 465.239 °C at 760 mmHg

Flash Point: 235.168 °C

Density: 1.518 g/cm3