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    4360-63-8

    Catalog No. EBD12900

    CAS 4360-63-8

    Name 2-Bromomethyl-1,3-dioxolane

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    Basic Information

    Synonyms: 1,3-dioxolane,2-(bromomethyl)- 2-(Bromomethyl)-1,3-dioxolane Bromoacetaldehydeethyleneacetal 2-Bromomethyl-1,3-dioxolane

    Molecular Formula: C4H7BrO2

    Molecular Weight: 167.0

    MDL Number: MFCD00003214

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones

    Product Description:
    2-Bromomethyl-1,3-dioxolane is a bifunctional organic building block featuring a bromomethyl group attached to a 1,3-dioxolane ring. The dioxolane moiety serves as a protected aldehyde equivalent, while the bromomethyl group acts as a reactive alkylating handle. This structure makes it a versatile reagent in organic synthesis, particularly for introducing a protected formyl group via nucleophilic substitution or cross-coupling reactions. Its primary application lies in synthetic chemistry as a halogenated building block for constructing complex molecules, including pharmaceuticals and agrochemicals. In medicinal chemistry, it is frequently employed as a small molecule fragment for drug discovery, enabling the installation of acetal-protected aldehyde functionalities into lead compounds. The compound is also used in the synthesis of heterocycles and as a precursor for functionalized polymers. Due to its reactivity, it should be handled with care under inert conditions to avoid hydrolysis or decomposition.
    Physical Properties

    Boiling Point: 80-82 °C/27 mmHg(lit.)

    Flash Point: 62 °C

    Density: 1.613 g/mL at 25 °C(lit.)

    Refractivity: n20/D 1.482(lit.)

    Analytical Data

    Appearance: clear colorless liquid

    mg g kg ml l t