3-hydroxybutanenitrile, CAS No. 4368-06-3

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4368-06-3

Catalog No. EBD106368

CAS 4368-06-3

Name 3-hydroxybutanenitrile

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Basic Information

Synonyms: 3-hydroxybutanenitrile 3-Hydroxybutyronitrile beta-Hydroxybutyronitrile butanenitrile,3-hydroxy- b-hydroxybutyronitrile 2-cyanoisopropylalcohol butyronitrile,3-hydroxy-(6ci,7ci,8ci)

Molecular Formula: C4H7NO

Molecular Weight: 85.1

MDL Number: MFCD03427120

Categories: Synthetic Chemistry > Organic Building Blocks > Cyano Compounds Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones

Product Description:

3-Hydroxybutyronitrile is an organic compound with the molecular formula C4H7NO. It is a bifunctional molecule containing both a nitrile group and a secondary alcohol group. This structure makes it a versatile chiral building block in organic synthesis. Its primary application is as a key intermediate in the synthesis of various pharmaceuticals and fine chemicals. Most notably, it serves as a crucial precursor in the production of the cholesterol-lowering drug Atorvastatin (Lipitor). The molecule's chiral center allows for the construction of complex, biologically active structures. It is also used in the synthesis of other β-hydroxy nitriles and β-amino alcohols, which are important motifs in medicinal chemistry. The compound is typically handled as a liquid and requires careful storage due to the reactivity of both functional groups. Its utility stems from the ability to further transform the nitrile group into carboxylic acids, amides, or amines, while the hydroxyl group can participate in protection, oxidation, or substitution reactions.

Physical Properties

Boiling Point: 214 °C(lit.)

Flash Point: 110 °C

Density: 0.976 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.429(lit.)

Analytical Data

Appearance: clear slightly yellow to amber liquid