2-Fluorobenzoic acid, CAS No. 445-29-4

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445-29-4

Catalog No. EBD7134

CAS 445-29-4

Name 2-Fluorobenzoic acid

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Basic Information

Synonyms: 2-Fluorobenzoicacid Fluorobenzoicacidminwhitepowder O-Fluorobenzoicacid 2,6-dinitro-4-(trifluoromethyl)aniline 2-fluorobenzoate

Molecular Formula: C7H5FO2

Molecular Weight: 140.11

MDL Number: MFCD00002405

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

2-Fluorobenzoic acid is an organic compound featuring a benzene ring substituted with a fluorine atom at the ortho position and a carboxylic acid group. It is a white to off-white crystalline solid with a molecular weight of 140.11 g/mol. The presence of the fluorine atom significantly alters the electronic properties and metabolic stability of the molecule, making it a valuable building block in medicinal chemistry. This compound serves as a key intermediate in the synthesis of various pharmaceuticals, particularly in the development of non-steroidal anti-inflammatory drugs (NSAIDs), antipsychotics, and antifungal agents. The fluorine substituent enhances the lipophilicity and bioavailability of drug candidates. Additionally, it is utilized in the preparation of agrochemicals and specialty materials. As a versatile synthetic building block, 2-fluorobenzoic acid is commonly employed in cross-coupling reactions, such as Suzuki-Miyaura coupling, and as a precursor for fluorinated benzoyl derivatives. It should be stored in a cool, dry place away from strong oxidizers. Standard laboratory safety precautions, including the use of gloves and eye protection, are recommended during handling.

Physical Properties

Melting Point: 122-125 °C(lit.)

Boiling Point: 244.7 °C at 760 mmHg

Flash Point: 101.8 °C

Density: 1,46 g/cm3

Solubility: 7200 mg/L at 25 °C in water

Analytical Data

Appearance: white to light yellow crystal powder