5-Nitrothiophene-2-carboxaldehyde, CAS No. 4521-33-9

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4521-33-9

Catalog No. EBD6909

CAS 4521-33-9

Name 5-Nitrothiophene-2-carboxaldehyde

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Basic Information

Synonyms: 5-Nitrothiophene-2-carboxaldehyde

Molecular Formula: C5H3NO3S

Molecular Weight: 157.15

MDL Number: MFCD00005433

Categories: Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones

Product Description:

5-Nitrothiophene-2-carboxaldehyde is a heterocyclic building block featuring a thiophene ring substituted with a nitro group at the 5-position and an aldehyde group at the 2-position. This compound is primarily utilized as a key intermediate in the synthesis of pharmaceutical agents, particularly those targeting antimicrobial and anti-inflammatory pathways. Its electron-deficient thiophene core, due to the nitro group, makes it a versatile precursor for constructing bioactive molecules via condensation or cross-coupling reactions. Additionally, it serves as a synthetic intermediate in the preparation of functional materials and agrochemicals. The compound is typically handled under inert atmosphere to prevent aldehyde oxidation and is classified as a hazardous irritant.

Physical Properties

Melting Point: 75-77 °C(lit.)

Boiling Point: 297.2 °C at 760 mmHg

Flash Point: 133.5 °C

Density: 1.534 g/cm3

Analytical Data

Appearance: yellow solid