4-(Trifluoromethyl)aniline, CAS No. 455-14-1

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455-14-1

Catalog No. EBD1101896

CAS 455-14-1

Name 4-(Trifluoromethyl)aniline

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Basic Information

Synonyms: p-Trifluoromethylaniline trifluoromehylphenylanilide 4-trifluoromethylaniline 4-AminoTrifluorotoluene Aminobenzotrifluoride,4-

Molecular Formula: C7H6F3N

Molecular Weight: 161.12

MDL Number: MFCD00064396

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

4-(Trifluoromethyl)aniline is an aromatic amine featuring a trifluoromethyl group (-CF_) at the para position relative to the amino group. This compound is a fundamental building block in medicinal chemistry, where the trifluoromethyl group is a critical pharmacophore known to enhance metabolic stability, lipophilicity, and bioavailability of drug candidates. Its primary application is as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs), including anti-inflammatory drugs (e.g., Flufenamic acid), antimalarial agents, and veterinary pharmaceuticals. The amino group allows for further functionalization through acylation, alkylation, or diazotization reactions, making it a versatile precursor for constructing complex heterocyclic systems and drug-like molecules. Beyond its role in drug development, this compound serves as a general synthetic building block for agrochemicals and functional materials. It is also widely used as a standard reagent in organic synthesis for introducing the trifluoromethylphenyl moiety into target molecules. Due to its toxicity, handling requires appropriate safety precautions, including the use of personal protective equipment and proper ventilation.

Physical Properties

Melting Point: 3-8 °C

Boiling Point: 83 °C/12 mmHg(lit.)

Flash Point: 87 °C

Density: 1.283 g/mL at 25 °C(lit.)

Solubility: <0.1 g/100 mL

Refractivity: n20/D 1.483(lit.)

Safety Information

Packing Level: 3

Hazard Category: 6.1/PG

Transport Codes: 2810

Analytical Data

Appearance: clear colorless to yellow liquid