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    473923-97-6

    Catalog No. EBD16024

    CAS 473923-97-6

    Name 3-Chloro-5-hydroxybenzonitrile

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    Basic Information

    Synonyms: 3-Chloro-5-hydroxybenzonitrile benzonitrile,3-chloro-5-hydroxy- 3-chloro-5-hydroxy-benzonitrile

    Molecular Formula: C7H4ClNO

    Molecular Weight: 153.57

    MDL Number: MFCD11226540

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Cyano Compounds

    Product Description:
    3-Chloro-5-hydroxybenzonitrile is an organic compound featuring a benzene ring substituted with a cyano group, a hydroxyl group, and a chlorine atom at the 1, 3, and 5 positions, respectively. It serves as a versatile and important chemical building block in pharmaceutical synthesis. Its primary and most significant application is as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). For instance, it is a crucial precursor in the manufacturing of certain kinase inhibitors and other small molecule therapeutics. The presence of both a reactive cyano group and a hydroxyl group allows for further functionalization, making it a valuable starting material for constructing more complex heterocyclic or substituted aromatic systems central to drug molecules. While its main utility lies in medicinal chemistry, its structural features also make it a useful synthon in general organic synthesis for introducing the benzonitrile moiety or for further transformations via the hydroxyl and chloro substituents.
    Physical Properties

    Boiling Point: 265.405 °C at 760 mmHg

    Flash Point: 114.313 °C

    mg g kg ml l t