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    50508-60-6

    Catalog No. EBD28485

    CAS 50508-60-6

    Name (2-Amino-5-ethylthiophen-3-yl)(2-chlorophenyl)methanone

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    Basic Information

    Synonyms: (2-amino-5-ethylthiophen-3-yl)(2-chlorophenyl)methanone (2-Amino-5-ethyl-3-thienyl)(2-chlorophenyl)methanone methanone,(2-amino-5-ethyl-3-thienyl)(2-chlorophenyl)- 2-Amino-3-(2-chlorobenzoyl)-5-ethylthiophene 2-Amino-3-o-chlorobenzoyl-5-ethylthiophene

    Molecular Formula: C13H12ClNOS

    Molecular Weight: 265.76

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Anti-infectives

    Product Description:
    2-Amino-3-o-chlorobenzoyl-5-ethylthiophene is a key heterocyclic organic compound featuring a thiophene ring substituted with an amino group, an o-chlorobenzoyl group, and an ethyl group. It serves as a crucial synthetic intermediate in the production of Cephalosporin antibiotics, specifically Cefaclor and Cefprozil. The compound's structure is integral to constructing the beta-lactam core and the side chains necessary for the antibacterial activity of these second-generation cephalosporins. Its primary industrial application is as a high-value pharmaceutical intermediate. The synthesis and purification of this compound are critical steps in the manufacturing process of Cefaclor, an oral antibiotic effective against a broad spectrum of bacteria. The presence of both the amino and benzoyl functionalities makes it a versatile building block for further chemical modifications in antibiotic synthesis. Due to its specific and dedicated use in the synthesis of established API drugs, it is not considered a general-purpose synthetic building block. Handling requires standard laboratory precautions for organic compounds, and its quality is strictly controlled to meet pharmaceutical-grade standards for impurity profiles.
    Physical Properties

    Boiling Point: 454.81 °C at 760 mmHg

    Flash Point: 228.861 °C

    Density: 1.302 g/cm3

    mg g kg ml l t